Phospho p38 MAPK Antibody Duo (Total, pThr180 / Tyr182)

Key features and details

产品描述: p38 MAP kinase (MAPK), also called RK or CSBP, is the mammalian orthologue of the yeast HOG kinase that participates in a signaling cascade controlling cellular responses to cytokines and stress. Four isoforms of p38 MAPK, p38α, β, γ (also known as Erk6 or SAPK3), and δ (also known as SAPK4) have been identified. p38 MAPK is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharide (LPS), UV light, and growth factors. MKK3, MKK6, and SEK activate p38 MAPK by phosphorylation at Thr180 and Tyr182. Activated p38 MAPK has been shown to phosphorylate and activate MAPKAP kinase 2 and to phosphorylate the transcription factors ATF-2 , Max, and MEF2.Rouse, J. et al. (1994) Cell 78, 1027-37.Han, J. et al. (1994) Science 265, 808-11.Lee, J.C. et al. (1994) Nature 372, 739-46.Freshney, N.W. et al. (1994) Cell 78, 1039-49.Raingeaud, J. et al. (1995) J Biol Chem 270, 7420-6.Zervos, A.S. et al. (1995) Proc Natl Acad Sci U S A 92, 10531-4.Yang, S.H. et al. (1999) Mol Cell Biol 19, 4028-38
靶点名称: p38 MAPK
別名: Phospho p38 MAPK antibody; Phospho Mitogen-activated protein kinase 14 antibody; p38 MAPK phospho (Thr180 / Tyr182) antibody; p38 MAPK antibody

Brand:

CAT.NO. : ARG30272

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Size:

1 pair

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Product Details

内含物

货号	内含物名称	宿主克隆性	反应	应用	包装
ARG55258	anti-p38 MAPK antibody	Rabbit pAb	Hu, Ms, Rat	ICC/IF, WB	50 μl
ARG51850	anti-p38 MAPK phospho (Thr180 / Tyr182) antibody	Rabbit pAb	Hu, Ms, Rat	WB	50 μl

概述

产品描述	p38 MAP kinase (MAPK), also called RK or CSBP, is the mammalian orthologue of the yeast HOG kinase that participates in a signaling cascade controlling cellular responses to cytokines and stress. Four isoforms of p38 MAPK, p38α, β, γ (also known as Erk6 or SAPK3), and δ (also known as SAPK4) have been identified. p38 MAPK is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharide (LPS), UV light, and growth factors. MKK3, MKK6, and SEK activate p38 MAPK by phosphorylation at Thr180 and Tyr182. Activated p38 MAPK has been shown to phosphorylate and activate MAPKAP kinase 2 and to phosphorylate the transcription factors ATF-2 , Max, and MEF2. Rouse, J. et al. (1994) Cell 78, 1027-37. Han, J. et al. (1994) Science 265, 808-11. Lee, J.C. et al. (1994) Nature 372, 739-46. Freshney, N.W. et al. (1994) Cell 78, 1039-49. Raingeaud, J. et al. (1995) J Biol Chem 270, 7420-6. Zervos, A.S. et al. (1995) Proc Natl Acad Sci U S A 92, 10531-4. Yang, S.H. et al. (1999) Mol Cell Biol 19, 4028-38
靶点名称	p38 MAPK
別名	Phospho p38 MAPK antibody; Phospho Mitogen-activated protein kinase 14 antibody; p38 MAPK phospho (Thr180 / Tyr182) antibody; p38 MAPK antibody

属性

存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

检测图片 (5)

ARG30272 Phospho-p38 MAPK Ab Duo (Total, pThr180/Tyr182) WB image
Western blot: 30 µg of HeLa treated with TNFa at 0, 10, 20, and 30 min. The blots stained with ARG51850 anti-P38 MAPK phospho (Thr180/Tyr182) antibody, ARG55258 anti-p38 MAPK antibody, and ARG65714 anti-Vinculin antibody.
ARG51850 anti-P38 MAPK phospho (Thr180/Tyr182) antibody WB image
Western Blot: extracts from HeLa cells untreated or treated with TNFa+CA stained with anti-P38 MAPK (phospho Thr180/Tyr182) antibody ARG51850.
ARG55258 anti-p38 MAPK antibody ICC/IF image
Immunofluorescence: A549 cell stained with ARG55258 anti-p38 MAPK antibody. Blue: DAPI for nuclear staining.
ARG55258 anti-p38 / MAPK14 antibody ICC/IF image
Immunofluorescence: A549 cell stained with ARG55258 anti-p38 / MAPK14 antibody. Blue: DAPI for nuclear staining.
ARG55258 anti-p38 MAPK antibody WB image
Western blot: 30 µg of HeLa, and Mouse liver lysate stained with ARG55258 anti-p38 MAPK antibody at 1:2000 dilution.

参考文献

HuMSC-EVs Protect Endothelial Cells Against Hypoxia/Reoxygenation Injury by Inhibiting the Pannexin 1/p38-MAPK Pathway

ARG51850: WB / Human

Qian Ma et al.
Transplantation Proceedings, (2024)

Shionone relieves oxygen-glucose deprivation/reoxygenation induced SH-SY5Y cells injury by inhibiting the p38 MAPK/NF-κB pathway

ARG51850: WB / Human

Xiaoli Zhou et al.
J Cardiothorac Surg, (2024)

Structural characterization and immunomodulatory activity of an acidic polysaccharide from walnut green husk

ARG51850: WB / Mouse

Guoliang Wang et al.
Journal of Functional Foods, (2023)

DHPA Protects SH-SY5Y Cells from Oxidative Stress-Induced Apoptosis via Mitochondria Apoptosis and the Keap1/Nrf2/HO-1 Signaling Pathway

ARG51850: WB / Human

Yunhui Cai et al.
Antioxidants (Basel), (2022)

Cobalt protoporphyrin promotes human keratinocyte migration under hyperglycemic conditions

ARG51850, ARG55258: WB / Human

Peng-Hsiang Fang et al.
Molecular Medicine, (2022)

Angiotensin II Induces Cardiac Edema and Hypertrophic Remodeling through Lymphatic-Dependent Mechanisms

ARG51850: WB / Mouse ARG55258: WB / Mouse

Jie Bai et al.
Oxid Med Cell Longev., (2022)

Shikonin Induced Program Cell Death through Generation of Reactive Oxygen Species in Renal Cancer Cells

ARG51850: WB / Human

Ming-Feng Tsai et al.
Antioxidants (Basel)., (2021)

Angiotensin-(1-7) treatment blocks lipopolysaccharide-induced organ damage, platelet dysfunction, and IL-6 and nitric oxide production in rats.

ARG51850: WB / Rat

Hsin-Jung Tsai et al.
Sci Rep., (2021)

Inhibition of inflammatory response by α-lipoic acid in autoimmune thyroiditis mice.

ARG55258: WB / Mouse

Mayinu Yusufu et al.
Basic & Clinical Medicine., (2021)

Discoidin Domain Receptor 1 Regulates Runx2 during Osteogenesis of Osteoblasts and Promotes Bone Ossification via Phosphorylation of p38.

ARG55258: WB / Mouse

Liang-Yin Chou et al.
Int J Mol Sci., (2020)

Polyphenols from Toona sinensiss Seeds Alleviate Neuroinflammation Induced by 6-Hydroxydopamine Through Suppressing p38 MAPK Signaling Pathway in a Rat Model of Parkinson's Disease.

ARG55258: WB, ICC/IF / Rat

Zhuang Wenxin et al.
Neurochem Res., (2020)

The Different Effects of IFN- β and IFN- γ on the Tumor-Suppressive Activity of Human Amniotic Fluid-Derived Mesenchymal Stem Cells

ARG51850: WB / Human

Jingchun Du et al.
Stem Cells Int., (2019)

Indirubin Inhibits LPS-Induced Inflammation via TLR4 Abrogation Mediated by the NF-kB and MAPK Signaling Pathways.

ARG55258: WB / Mouse

Lai JL et al.
Inflammation., (2016)

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