Phospho Raf1 Antibody Duo (Total, pS259)

产品描述: c-RAF, or RAF1 is a Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 can be deactivated through the phosphorylation by cyclic AMP-dependent protein Kinase (PKA) at various residues. Serine 43 phosphorylation decreased the binding to Ras in serum-starved cells. Mutation of Ser259 and Ser338 increased the basal Raf-1 activity. Dhillon et al. 2002. Mol Cell Biol 22(10):3237-46 Kubicek et al. 2002. J Biol Chem 277(10): 7913
靶点名称: Raf1
別名: Phospho Raf1 antibody; Raf1 antibody; Raf1 phospho (Ser259) antibody

CAT.NO. : ARG30220

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Size:

1 pair

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Product Details

内含物

货号	内含物名称	宿主克隆性	反应	应用	包装
ARG51510	anti-Raf1 phospho (Ser259) antibody	Rabbit pAb	Hu, Ms, Rat	IHC-P, WB	50 μl
ARG10060	anti-Raf1 antibody [410]	Mouse mAb	Hu	WB	50 μg

概述

产品描述	c-RAF, or RAF1 is a Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 can be deactivated through the phosphorylation by cyclic AMP-dependent protein Kinase (PKA) at various residues. Serine 43 phosphorylation decreased the binding to Ras in serum-starved cells. Mutation of Ser259 and Ser338 increased the basal Raf-1 activity. Dhillon et al. 2002. Mol Cell Biol 22(10):3237-46 Kubicek et al. 2002. J Biol Chem 277(10): 7913
靶点名称	Raf1
別名	Phospho Raf1 antibody; Raf1 antibody; Raf1 phospho (Ser259) antibody

属性

存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

全名	Phospho Raf1 Antibody Duo (Total, pS259)
研究领域	Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody; Signaling Transduction antibody

检测图片 (2)

ARG51510 anti-Raf1 phospho (Ser259) antibody WB image
Western Blot: extracts from 293 and MDA cells untreated or treated with PMA stained with anti-Raf1 (phospho Ser259) antibody ARG51510.
ARG51510 anti-Raf1 phospho (Ser259) antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-Raf1 (phospho Ser259) antibody ARG51510.

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