Phospho Smad1 for Activation / Inhibition site Antibody Panel

产品描述: Smad transcription factors convey downstream messages from the most versatile cytokine signaling pathways in the multicellular life forms, the transforming growth factor-β (TGFβ) pathway. Recent works has shed light into the processes and functions of SMAD activation and deactivation, nucleocytoplasmic dynamics, and assembly of transcriptional complexes. Smad proteins consist of two globular domains coupled by a linker region. Smad1 can be phosphorylated at the linker region (pSer206) where recruitment of Smurf takes place and results in the degradation of Smad1. On the other hands, phosphorylation of Smad1 at pSer465 translocate Smad1/Smad4 complex to nucleus and transcriptionally activate target genes. Whiteman et al. (1993) Genes Dev 12:2445-62 Massagué J et al. (2005) Genes Dev 19: 2783-2810 Sapkota et al. (2007) Mol Cell 25: 441-454
靶点名称: Smad1 for Activation / Inhibition site
別名: Phospho Smad1 for Activation / Inhibition site antibody; Smad 1 antibody; Smad 1 phospho (Ser465) antibody; Smad 1 phospho (Ser206) antibody

CAT.NO. : ARG30155

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Size:

1 kit

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

内含物

货号	内含物名称	宿主克隆性	反应	应用	包装
ARG51284	anti-Smad 1 antibody	Rabbit pAb	Hu, Ms, Rat	ICC/IF, WB	50 μl
ARG51848	anti-Smad 1 phospho (Ser206) antibody	Rabbit pAb	Hu, Ms, Rat	WB	50 μl
ARG51794	anti-Smad 1 phospho (Ser465) antibody	Rabbit pAb	Hu, Ms, Rat	WB	50 μl
ARG65351	Goat anti-Rabbit IgG antibody (HRP)	Goat pAb	Rb	ELISA, IHC-P, WB	50 μl

概述

产品描述	Smad transcription factors convey downstream messages from the most versatile cytokine signaling pathways in the multicellular life forms, the transforming growth factor-β (TGFβ) pathway. Recent works has shed light into the processes and functions of SMAD activation and deactivation, nucleocytoplasmic dynamics, and assembly of transcriptional complexes. Smad proteins consist of two globular domains coupled by a linker region. Smad1 can be phosphorylated at the linker region (pSer206) where recruitment of Smurf takes place and results in the degradation of Smad1. On the other hands, phosphorylation of Smad1 at pSer465 translocate Smad1/Smad4 complex to nucleus and transcriptionally activate target genes. Whiteman et al. (1993) Genes Dev 12:2445-62 Massagué J et al. (2005) Genes Dev 19: 2783-2810 Sapkota et al. (2007) Mol Cell 25: 441-454
靶点名称	Smad1 for Activation / Inhibition site
別名	Phospho Smad1 for Activation / Inhibition site antibody; Smad 1 antibody; Smad 1 phospho (Ser465) antibody; Smad 1 phospho (Ser206) antibody

属性

存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

全名	Antibody Panel for Phospho Smad1 for Activation / Inhibition site
研究领域	Cancer antibody; Developmental Biology antibody; Gene Regulation antibody; Immune System antibody; Metabolism antibody; Signaling Transduction antibody

检测图片 (4)

ARG51284 anti-Smad1 antibody WB image
Western Blot: extracts from HeLa cells stained with anti-Smad1 antibody ARG51284.
ARG51794 anti-Smad1 phospho (Ser465) antibody WB image
Western Blot: extracts from HeLa cells untreated or treated with PMA stained with anti-Smad1 (phospho Ser465) antibody ARG51794.
ARG51848 anti-Smad1 phospho (Ser206) antibody WB image
Western Blot: extracts from HeLa cells untreated or treated with PMA stained with anti-Smad1 (phospho Ser206) antibody ARG51848.
ARG51284 anti-Smad1 antibody ICC/IF image
Immunofluorescence: methanol-fixed HeLa cells stained with anti-Smad1 antibody ARG51284.

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