Phospho Tau Antibody Panel (Total, pS396, pS404)

Key features and details

  • 产品描述: Tau is a group of neuronal microtubule-associated proteins that are formed by alternative mRNA splicing and accumulate in neurofibrillary tangles in Alzheimer's disease (AD) brain. Tau plays a key role in regulating microtubule dynamics, axonal transport and neurite outgrowth, and all these functions of tau are modulated by site-specific phosphorylation. Phosphorylation of Tau (Isoform Tau-F) at Ser296 and Ser404 sites by Tau Protein Kinase II is responsible for the functional loss of tau-mediated tubulin polymerization in AD. Evans et al. 2000. J Biol Chem 275(32): 24977-83 Stoothoff and Johnson. 2005. Biochem Biophy Acta 1739(2-3): 280-97
  • 靶点名称: Tau
  • 別名: Phospho Tau antibody; Tau antibody; Tau phospho (Ser396) antibody; Tau phospho (Ser404) antibody
  • Brand:
CAT.NO. : ARG30211
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Product Details
内含物
货号内含物名称宿主克隆性反应应用包装
ARG51614anti-Tau phospho (Ser404) antibodyRabbit pAbHu, Ms, RatICC/IF, IHC-P, WB50 μl
ARG51604anti-Tau phospho (Ser396) antibodyRabbit pAbHu, Ms, RatIHC-P, WB50 μl
ARG51094anti-Tau antibodyRabbit pAbHu, Ms, RatIHC-P, WB50 μl
ARG65351Goat anti-Rabbit IgG antibody (HRP)Goat pAbRbELISA, IHC-P, WB50 μl
概述
产品描述Tau is a group of neuronal microtubule-associated proteins that are formed by alternative mRNA splicing and accumulate in neurofibrillary tangles in Alzheimer's disease (AD) brain. Tau plays a key role in regulating microtubule dynamics, axonal transport and neurite outgrowth, and all these functions of tau are modulated by site-specific phosphorylation. Phosphorylation of Tau (Isoform Tau-F) at Ser296 and Ser404 sites by Tau Protein Kinase II is responsible for the functional loss of tau-mediated tubulin polymerization in AD. Evans et al. 2000. J Biol Chem 275(32): 24977-83 Stoothoff and Johnson. 2005. Biochem Biophy Acta 1739(2-3): 280-97
靶点名称Tau
別名Phospho Tau antibody; Tau antibody; Tau phospho (Ser396) antibody; Tau phospho (Ser404) antibody
属性
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
全名Antibody Panel for Phospho Tau (Total, pS396, pS404)
研究领域Immune System antibody; Neuroscience antibody; Signaling Transduction antibody
检测图片 (11)
  • ARG51094 anti-Tau antibody WB image

    Western blot: 30 µg of 1) Mouse brain and 2) Rat brain tissue lysate stained with ARG51094 anti-Tau antibody at 1:500 dilution.

  • ARG51604 anti-Tau phospho (Ser396) antibody WB image

    Western blot: 30 µg of 1) Mouse brain and 2) Rat brain tissue lysate stained with ARG51604 anti-Tau phospho (Ser396) antibody at 1:500 dilution.

  • ARG51614 anti-Tau phospho (Ser404) antibody WB image

    Western blot: 30 µg of Mouse brain and Rat brain tissue lysates stained with ARG51614 anti-Tau phospho (Ser404) antibody at 1:500 dilution.

  • ARG51094 anti-Tau antibody WB image

    Western Blot: extracts from mouse brain tissue stained with anti-Tau antibody ARG51094.

  • ARG51094 anti-Tau antibody IHC-P image

    Immunohistochemistry: paraffin-embedded rat hippocampal region tissue from a model with Alzheimer stained with anti-Tau antibody ARG51094

  • ARG51604 anti-Tau phospho (Ser396) Antibody WB image

    Western Blot: extracts from mouse brain tissue stained with anti-Hsp90 antibody [D7 alpha] ARG51604 and the same antibody preincubated with blocking peptide.

  • ARG51604 anti-Tau phospho (Ser396) Antibody IHC-P image

    Immunohistochemistry: paraffin-embedded rat hippocampal region tissue from a model with Alzheimer stained with anti-Hsp90 antibody [D7 alpha] ARG51604

  • ARG51614 anti-Tau phospho (Ser404) antibody WB image

    Western Blot: extracts from C6 cells, treated with calf intestinal phosphatase (CIP), stained with anti-Tau (phospho Ser404) antibody ARG51614.

  • ARG51614 anti-Tau phospho (Ser404) antibody IHC-P image

    Immunohistochemistry: paraffin-embedded rat hippocampal region tissue from a model with Alzheimer stained with anti-Tau (phospho Ser404) antibody ARG51614

  • ARG51614 anti-Tau phospho (Ser404) antibody ICC/IF image

    Immunofluorescence: methanol-fixed HeLa cells stained with anti-Tau (phospho Ser404) antibody ARG51614.

  • ARG51614 anti-Tau phospho (Ser404) antibody WB image

    Western Blot: extracts from C6 cells stained with anti-Tau (phospho Ser404) antibody ARG51614.

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