Phospho Tyrosine Hydroxylase Antibody Panel (Total, pS31, pS40)

Key features and details

  • 产品描述: Tyrosine Hydroxylase (TH) is an enzyme responsible for catalyzing the conversion of L-tyrosine to L-DOPA, a precursor for an important neurotransmitter Dopamine. TH activity is regulated by its phosphorylation. The phosphorylation of TH at Ser31 and Ser40 residues was found to enhance dopamine synthesis in primary neurons. Daubner, Le and Wang. 2011. Arch Biochem Biophy 508(1):1-12 Kobori et al. 2004. J Biol Chem 279(3): 2182-91Related news:Astrocyte-to-neuron conversion for Parkinson's disease treatment
  • 靶点名称: Tyrosine Hydroxylase
  • 別名: Phospho Tyrosine Hydroxylase antibody; Tyrosine Hydroxylase antibody; Tyrosine Hydroxylase phospho (Ser31) antibody; Tyrosine Hydroxylase phospho (Ser40) antibody
  • Brand:
CAT.NO. : ARG30212
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Product Details
内含物
货号内含物名称宿主克隆性反应应用包装
ARG52464anti-Tyrosine Hydroxylase phospho (Ser40) antibodyRabbit pAbHu, Ms, Rat, MammICC/IF, IHC, WB50 μl
ARG52463anti-Tyrosine Hydroxylase phospho (Ser31) antibodyRabbit pAbMs, RatICC/IF, IHC, WB50 μl
ARG52461anti-Tyrosine Hydroxylase antibodyRabbit pAbHu, Ms, Rat, MammICC/IF, IHC-Fr, IHC-P, WB50 μl
ARG65351Goat anti-Rabbit IgG antibody (HRP)Goat pAbRbELISA, IHC-P, WB50 μl
概述
产品描述Tyrosine Hydroxylase (TH) is an enzyme responsible for catalyzing the conversion of L-tyrosine to L-DOPA, a precursor for an important neurotransmitter Dopamine. TH activity is regulated by its phosphorylation. The phosphorylation of TH at Ser31 and Ser40 residues was found to enhance dopamine synthesis in primary neurons. Daubner, Le and Wang. 2011. Arch Biochem Biophy 508(1):1-12 Kobori et al. 2004. J Biol Chem 279(3): 2182-91

Related news:
Astrocyte-to-neuron conversion for Parkinson's disease treatment
靶点名称Tyrosine Hydroxylase
別名Phospho Tyrosine Hydroxylase antibody; Tyrosine Hydroxylase antibody; Tyrosine Hydroxylase phospho (Ser31) antibody; Tyrosine Hydroxylase phospho (Ser40) antibody
属性
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
全名Antibody Panel for Phospho Tyrosine Hydroxylase (Total, pS31, pS40)
研究领域Cancer antibody; Immune System antibody; Metabolism antibody; Neuroscience antibody
检测图片 (7)
  • ARG52461 anti-Tyrosine Hydroxylase antibody WB image

    Western blot: 30 µg of Mouse brain tissue lysate stained with ARG52461 anti-Tyrosine Hydroxylase antibody at 1:500 dilution.

  • ARG52461 anti-Tyrosine Hydroxylase antibody ICC/IF image

    Immunofluorescence: E17 Rat midbrain mixed neuronal cultures stained with ARG52461 anti-Tyrosine Hydroxylase antibody (green) and ARG52328 anti-MAP2 antibody (red).

  • ARG52464 anti-Tyrosine Hydroxylase phospho (Ser40) antibody WB image

    Western blot: Recombinant phospho- and dephospho-Tyrosine Hydroxylase. The blots were stained with anti-pan Tyrosine Hydroxylase antibody and ARG52464 anti-Tyrosine Hydroxylase phospho (Ser40) antibody.

  • ARG52461 anti-Tyrosine Hydroxylase antibody IHC-Fr image

    Immunohistochemistry: Frozen section of Mouse brain stained with ARG52461 anti-Tyrosine Hydroxylase antibody at 1:1000 dilution.

  • ARG52461 anti-TH antibody WB image

    Western Blot: 10 μg of rat caudate lysate showing specific immunolabeling of the ~60k TH protein stained with TH antibody (ARG52461).

  • ARG52463 anti-Tyrosine Hydroxylase phospho (Ser31) antibody WB image

    Western blot: PC-12 cells incubated in the absence (Control) and presence of okadaic acid (OA, 1 µM for 60 min) showing specific immunolabeling of the ~60 kDa TH phosphorylated at Ser31 stained with ARG52463 anti-Tyrosine Hydroxylase phospho (Ser31) antibody.

  • ARG52464 anti-Tyrosine Hydroxylase phospho (Ser40) antibody IHC image

    Immunohistochemistry: Light-stimulated Rabbit retina stained with ARG52464 anti-Tyrosine Hydroxylase phospho (Ser40) antibody showing labeling of TH when phosphorylated at Ser40.

参考文献

Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation

ARG52461: Imaging Cytometry / Human

Yu-Che Cheng et al.
Stem Cell Rev Rep.,  (2022)

publication_link

 

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