Phosphohistone H3 (PHH3) Mouse Monoclonal Antibody(ARM554)
Key features and details
- Target:
- Clone ID:
- Host Species:
- Species Cross-reactivity:
- Applications:
- Dilution:
- Clonality:
-
Brand:
CAT.NO. : ARM6844
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
Phosphohistone H3 (PHH3) is a histone protein involved in forming the major protein structure of chromatin in eukaryotic cells. Anti-Phosphohistone H3 (PHH3) has been shown to be specific for the core protein histone H3 only when phosphorylated at serine 10 or serine 28, deeming PHH3 useful as a mitotic marker for differentiating mitotic figures from apoptotic bodies and karyorrhectic debris, since phosphorylation on histone H3 is not detected during apoptosis. Phosphohistone H3 may therefore be useful in diagnosis of tumour grades, especially in central nervous system, skin, gynecological, soft tissue, and gastrointestinal stromal tumours. Immunohistochemical staining with Anti-PHH3 has also been considered highly useful in prognosis of breast cancer, melanoma, and meningiomas.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:50 - 1:200 |
Overview
|
Isotype |
IgG |
|
Host |
Rabbit |
|
Species Reactivity |
Human |
|
Purity/Purification |
Purified |
|
Form/Format |
Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide |
|
Immunogen |
Recombinant Protein |
Data
Immunohistochemical staining of human tonsil tissue using Phosphohistone H3 (PHH3) Mouse Monoclonal Antibody (ARM554).
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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