PHOX2B Rabbit Monoclonal Antibody(ARB527)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6819
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Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
Paired - like homeobox 2B (PHOX2B) is a transcription factor located on chromosome 4p13 which is crucial to the formation of autonomic ganglia in the autonomic nervous system (ANS). The PHOX2B gene is strictly expressed in neural crest derivatives committed to the noradrenergic phenotype. The PHOX2B gene encodes a paired - like homeo - domain transcription factor with an extra - axial expression pattern restricted to the ANS. Neuroblasts of peripheral neuroblastic tumors are derived from the sympathoadrenal lineage, a division of the ANS. PHOX2B has been observed in peripheral neuroblastic tumors, neuroblastomas, paragangliomas, ganglioneuroblastomas, ganglioneuromas and pheochromocytomas. PHOX2B has been reported to be negative in other small round blue cell tumors.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100-1:200 |
Overview
|
Target |
PHOX2B |
|
Host Species |
rabbit monoclonal antibody |
|
Molecular Weight |
32 kDa |
|
Purity |
ProA affinity purified IgG |
|
Species Cross-reactivity |
Human |
|
Form |
Liquid |
|
Applications |
IHC-P |
|
Swissprot ID |
Q99453 |
|
Immunogen |
Synthetic peptide residues in human PHOX2B |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
|
Storage Conditions |
-25°C to -18°C |
|
Dilutions |
IHC-P: 1:100-1:200 |
|
Subcellular Location |
Nucleus |
|
Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), RT for 30 min |
Data
Immunohistochemical staining of human neuroblastoma tissue sections using PHOX2B Rabbit Monoclonal Antibody (ARB527).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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