PKA alpha/beta/gamma cat Rabbit Polyclonal Antibody

Key features and details

Reactivity:Human, Mouse, Rat
Application:WB, IHC, IF/ICC
Host:Rabbit
Clonality:Polyclonal
lsotype: IgG
Target:PKA alpha/beta/gamma cat

Brand:

CAT.NO. : ARA6508

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Size:

50μL 100μL

Trail, Bulk size or Custom requests Please contact us

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Product Details

Background

This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome.

Application

Application	Dilution Ratio
WB	1:500 - 1:2000
IHC	1:100 - 1:300
IF/ICC	1:100 - 1:500

Overview

Product Name	PKA alpha/beta/gamma cat Rabbit Polyclonal Antibody
Antibody Type	Rabbit Polyclonal Antibody
Immunogen	The antiserum was produced against synthesized peptide derived from human PKA alpha/beta CAT. AA range:166-215
Species Reactivity	Human, Mouse, Rat
Validated Applications	WB, IHC, IF
Molecular Weight	40 kDa
Positive Control	Amnion, Epithelium, Eye, Sperm, Testis, Thalamus
Conjugation	unconjugated
Form	Liquid
Storage Buffer	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Isotype	IgG
Purification Method	Immunogen affinity purified.