PMEL17 Rabbit Monoclonal Antibody(ARB530)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6822
RMB Please choose
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Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
.
PMEL 17 is a melanosome specific antigen, also is designed as HMB45 or gp100. It plays a central role in the biogenesis of melanosomes, involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures.
PMEL 17 is presented in immature and activated melanocytes (due to, e.g., inflammation, increased vascularity or underlying tumor), but not in mature, resting melanocytes. In tumor tissues, it is restricted expressed in melanoma.
Studies support the routine use of PMEL 17 (HMB45) as a sensitive and specific melanocytic marker.
PMEL 17 is a melanosome specific antigen, also is designed as HMB45 or gp100. It plays a central role in the biogenesis of melanosomes, involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures.
PMEL 17 is presented in immature and activated melanocytes (due to, e.g., inflammation, increased vascularity or underlying tumor), but not in mature, resting melanocytes. In tumor tissues, it is restricted expressed in melanoma.
Studies support the routine use of PMEL 17 (HMB45) as a sensitive and specific melanocytic marker.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:200 |
Overview
|
Predicted Molecular Wt |
70kDa |
|
Species Cross-reactivity |
Human |
|
Applications |
IHC-P |
|
Purity |
ProA affinity purified IgG |
|
Form |
Liquid |
|
Swissprot ID |
P40967 |
|
Subcellular location |
Cytoplasm |
|
Recommended method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes |
|
Immunogen |
Synthetic peptide corresponding to PMEL 17 residues within aa561-661 of PMEL 17 was used as an immunogen |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
Data
Immunohistochemical staining of human melanoma tissue using PMEL17 Rabbit Monoclonal Antibody(ARB530)
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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