Podoplanin Rabbit Monoclonal Antibody(ARB531)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6823
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Size:
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Product Details
Background
Podoplanin was first identified as a transmembrane glycoprotein in the podocytes of rat kidney. Podoplanin acts as receptor for selectins (which mediate inflammatory cell adhesion) and is involved in cell maturation and migration by filopodia formation (via the downregulation of the activities of small Rho family GTPases).
Podoplanin is found in lymphatic endothelium (but not blood vessel endothelial cells), fibroblasts, osteocytes, follicular dendritic cells, smooth and striated muscle cells, myoepithelial cells, Cajal cells, basal cells in squamous epithelium (tonsil), gastric crypt cells, prostatic basal cells, immature Sertoli cells and foetal gonocytes (but not the corresponding cells of the adult testis), renal glomerular podocytes, mesothelium (particularly when reactive), subsets of lymphocytes, Schwann cells, glial and ependymal cells.
Podoplanin is a very useful marker in the differentiation between malignant mesothelioma and adenocarcinoma, and the identification of seminoma/dysgerminoma/IGCN.
Podoplanin is found in lymphatic endothelium (but not blood vessel endothelial cells), fibroblasts, osteocytes, follicular dendritic cells, smooth and striated muscle cells, myoepithelial cells, Cajal cells, basal cells in squamous epithelium (tonsil), gastric crypt cells, prostatic basal cells, immature Sertoli cells and foetal gonocytes (but not the corresponding cells of the adult testis), renal glomerular podocytes, mesothelium (particularly when reactive), subsets of lymphocytes, Schwann cells, glial and ependymal cells.
Podoplanin is a very useful marker in the differentiation between malignant mesothelioma and adenocarcinoma, and the identification of seminoma/dysgerminoma/IGCN.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:200 |
Overview
|
Predicted Molecular Wt |
17kDa |
|
Species Cross-reactivity |
Human |
|
Applications |
IHC-P |
|
Purity |
ProA affinity purified IgG |
|
Form |
Liquid |
|
Swissprot ID |
Q86YL7 |
|
Subcellular location |
Membrane |
|
Recommended method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes |
|
Immunogen |
Synthetic peptide corresponding to residues within aa1-100 of Podoplanin was used as an immunogen |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
Data
Immunohistochemical staining of human diffuse large B-cell lymphoma tissue using Podoplanin Rabbit Monoclonal Antibody(ARB531)
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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