PRAME Rabbit Monoclonal Antibody(ARB532)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6824
RMB Please choose
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Size:
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Product Details
Background
Cancer/testis antigens (CTAs) are a family of more than 100 proteins whose normal expression is largely restricted to immune privileged germ cells of the testis, ovary, and trophoblast cells of the placenta. Although most normal somatic tissues are void of CTA expression, due to epigenetic silencing of gene expression, their expression is upregulated in a wide variety of human solid and liquid tumors.
PRAME (preferentially expressed antigen in melanoma) is a cancer/testis antigen not normally expressed in any tissues except testis, but is upregulated in tumors. PRAME is expressed in melanoma cells and is recognized by cytolytic T - cells. It is also upregulated in other diseases, such as synovial sarcoma, NSCLC, and breast cancer, where it is thought to contribute to tumorigenesis and metastasis. PRAME is also highly expressed in liquid tumors such as AML and can be predictive of clinical outcome in some circumstances.
PRAME and other cancer/testis antigens are currently being pursued as novel immunotherapy targets and diagnostic biomarkers.
PRAME (preferentially expressed antigen in melanoma) is a cancer/testis antigen not normally expressed in any tissues except testis, but is upregulated in tumors. PRAME is expressed in melanoma cells and is recognized by cytolytic T - cells. It is also upregulated in other diseases, such as synovial sarcoma, NSCLC, and breast cancer, where it is thought to contribute to tumorigenesis and metastasis. PRAME is also highly expressed in liquid tumors such as AML and can be predictive of clinical outcome in some circumstances.
PRAME and other cancer/testis antigens are currently being pursued as novel immunotherapy targets and diagnostic biomarkers.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:200 |
Overview
|
Predicted Molecular Wt |
17kDa |
|
Species Cross-reactivity |
Human |
|
Applications |
IHC-P |
|
Purity |
ProA affinity purified IgG |
|
Form |
Liquid |
|
Swissprot ID |
Q86YL7 |
|
Subcellular location |
Membrane |
|
Recommended method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes |
|
Immunogen |
Synthetic peptide corresponding to residues within aa1-100 of Podoplanin was used as an immunogen |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
Data
Immunohistochemical staining of human malignant melanoma tissue using PRAME Rabbit Monoclonal Antibody(ARB532)
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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