pS2 Rabbit Monoclonal Antibody(ARA923)

Key features and details

Reactivity:Human
Application:IHC
Host:Rabbit
Clonality:Monoclonal
Target:pS2

Brand:

CAT.NO. : ARA6758

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Size:

1mL

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Product Details

Background

Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. pS2, also designated Md2, BCEI, TFF1 and pNR-2, is a trefoil protein that is highly expressed in normal gastric mucosa. pS2 has also been detected in a number of carcinomas including cancers of the breast, pancreas and stomach. pS2 is not present in normal breast tissue but is inducible by estrogen in MCF7 cells. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. The gene encoding pS2 maps to human chromosome 21q22.3.

Application

Application	Dilution Ratio
IHC-P	1:200-:1000

Overview

Antibody Type	Recombinant Rabbit monoclonal Antibody
Immunogen	Synthetic peptide within Human Estrogen Inducible Protein pS2 aa 35-84 / 84
Species Reactivity	Human
Validated Applications	WB, IF-Cell, IF-Tissue, IHC-P, IP, FC
Molecular Weight	Predicted band size: 9 kDa
Positive Control	MCF7 cell lysate, MCF7, human stomach tissue, human stomach carcinoma tissue, human breast carcinoma tissue, human pancreas tissue
Conjugation	unconjugated
Form	Liquid
Concentration	1μg/μl
Storage Buffer	1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide
Isotype	IgG
Purification Method	Protein A affinity purified