pTau181 Mouse Monoclonal Antibody (ARA989)
Key features and details
- Reactivity:Human
- Application:Sandwich ELISA
- Host:Mouse
- Clonality:Monoclonal
- Target:pTau181
-
Brand:
CAT.NO. : ARA6887
RMB Please choose
RMB Please choose
*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。
Product Details
Background
Plasma phosphorylated tau 181 (p-tau181) has emerged as a promising biomarker for Alzheimer’s disease (AD) and related conditions. Studies show that elevated plasma p-tau181 levels are associated with increased amyloid-beta (Aβ) deposits across various brain regions in cognitively healthy adults. Furthermore, p-tau181 levels correlate with Aβ-positivity on positron emission tomography (PET), and they predict the conversion to dementia stage depending on tau-PET burden. However, p-tau181 does not appear to be directly linked to renal function. Additionally, plasma p-tau181 levels have been associated with cognitive decline in various populations, such as those with AD, mild cognitive impairment (MCI), and other neurodegenerative diseases. Moreover, p-tau181 levels have been identified as a noninvasive diagnostic and prognostic tool in clinical practice and trials.
Application
| Recommended dilution ratio | |
|---|---|
| Sandwich ELISA | 1:250~1:500 |
Formulation
| ARA6887 | Phosphate-buffered saline (PBS), carrier-free, with optional 0.09% sodium azide |
|---|---|
| ARA6887-T5/20/50/100 | Phosphate-buffered saline (PBS) with 50% glycerol, 0.5% BSA and 0.09% sodium azide |
Overview
|
Antibody specificity |
pTau181 peptide |
|
Species reactivity |
Human |
|
Clonality |
Monoclonal |
|
Host / isotype |
Mouse / IgG2b |
|
Immunogen |
Human MAPT peptide |
|
Cross reactivity |
Not tested |
|
Recombinant |
Not recombinant |
|
Purification |
Protein A purification |
|
Form |
Liquid |
|
Conjugation |
Unconjugated |
Data
Sandwich ELISA analysis of pTau181 by ARA6887 & mouse anti-human MAPT monoclonal antibody.
Microtiter wells were coated with ARA6887 as the capture antibody. Phosphorylated MAPT was used as the antigen. Peroxidase conjugated mouse anti-human MAPT monoclonal antibody was used as the detection antibody.
Result: ARA6887 and mouse anti-human MAPT monoclonal antibody can be used as a matched antibody pair to detect and quantify the concentration of pTau181.
Storage
Shipped at ambient temperature or with ice packs. Avoid repeated freeze-thaw cycles.
Upon receipt,
* 1 month when stored at 2 to 8 °C
* 12 months when aliquoted and stored at -20 °C or below
Upon receipt,
* 1 month when stored at 2 to 8 °C
* 12 months when aliquoted and stored at -20 °C or below
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
New Products
