PTEN Rabbit Monoclonal Antibody(ARB537)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6829
RMB Please choose
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Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
PTEN acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Tumor suppressor, the lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation.
PTEN gene is a tumor suppressor gene that maps to chromosome 10q23. PTEN is the first oncogene with bispecific phosphatase activity discovered in humans, regulating tumor cell growth, apoptosis and migration, etc. PTEN is found to be inactivated in a variety of tumours, and its inactivation is due to methylation modifications in addition to common mutations. High-grade endometrioid carcinomas are commonly deficient in PTEN expression.
PTEN gene deletion has also been found in glioblastoma, prostate cancer, melanoma, and breast cancer.
PTEN gene is a tumor suppressor gene that maps to chromosome 10q23. PTEN is the first oncogene with bispecific phosphatase activity discovered in humans, regulating tumor cell growth, apoptosis and migration, etc. PTEN is found to be inactivated in a variety of tumours, and its inactivation is due to methylation modifications in addition to common mutations. High-grade endometrioid carcinomas are commonly deficient in PTEN expression.
PTEN gene deletion has also been found in glioblastoma, prostate cancer, melanoma, and breast cancer.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:200 |
Overview
|
Predicted Molecular Wt |
54kDa |
|
Species Cross-reactivity |
Human |
|
Applications |
IHC-P |
|
Purity |
ProA affinity purified IgG |
|
Form |
Liquid |
|
Swissprot ID |
P60484 |
|
Subcellular location |
Cytoplasm, Nucleus |
|
Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
Data
Immunohistochemical staining of human endometrial carcinoma tissue using PTEN Rabbit Monoclonal Antibody(ARB537)
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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