Rb Rabbit Monoclonal Antibody(ARA919)
Key features and details
- Reactivity:Human, Mouse
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:Rb
-
Brand:
CAT.NO. : ARA6754
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, inactivating it, and the cell cycle is allowed to progress. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomavirus, bind and inactivate pRb, this can lead to cancer. The RB gene may have been responsible for the evolution of multicellularity in several lineages of life including animals.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:50-1:2000 |
Overview
|
Antibody Type |
Recombinant Rabbit monoclonal Antibody |
|
Immunogen |
Recombinant protein within mouse Rb aa 682-921 / 921 |
|
Species Reactivity |
Human, Mouse |
|
Validated Applications |
WB, IF-Cell, IF-Tissue, IHC-P, IP |
|
Molecular Weight |
Predicted band size: 106 kDa |
|
Positive Control |
Mouse lung tissue lysates, SW480, human spleen tissue, human breast carcinoma tissue, human colon tissue, human colon carcinoma tissue |
|
Conjugation |
unconjugated |
|
Form |
Liquid |
|
Concentration |
1μg/μl |
|
Storage Buffer |
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical staining of human colon carcinoma tissue using Rb Rabbit Monoclonal Antibody(ARA919)
Immunohistochemical staining of human breast carcinoma tissue using Rb Rabbit Monoclonal Antibody(ARA919)
Immunohistochemical staining of human colon tissue using Rb Rabbit Monoclonal Antibody(ARA919)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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