Recombinant Diphtheria Toxin Mutant CRM197

Key features and details

Species:
Abbreviation: rCRM197
Source: Expressed in E. coli.
Molecular Weight: Approximately 58.4 kDa, a single non-glycosylated polypeptide chain containing 535 amino acids
Purity: ＞96% by SDS-PAGE or HPLC, dimers and high molecular weight impurities: <4% by SEC-HPLC.
Endotoxin: < 0.01 EU/μg of rCRM197 protein as determined by LAL method.
Accession #: AMV91693 Gly2-Ser536
Storage: -20.0°C

Brand:

CAT.NO. : ARP6653

RMB Please choose

Size:

1mg

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Product Details

Background

CRM197 is a non-toxic mutant of diphtheria toxin having a single amino acid substitution of glycine with glutamic acid. CRM197 is a well-defined protein and functions as a carrier for polysaccharides and haptens making them more immunogenic. CRM197 is utilized as a carrier protein in a number of approved conjugate vaccines for diseases caused by Streptococcus pneumoniae, Haemophilus influenzae b and Neisseria meningitidis. Recombinant CRM197 is a 58.4kDa globular protein containing 535 amino acids.

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