Recombinant Human Hemofiltrate CC Chemokine-1/CCL14
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CAT.NO. : ARP6670
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Product Details
Background
Human CCL14 is belonging to the CC chemokine family. It has two isoforms, CCL14a (HCC-1) and CCL14b (HCC-3) . The sequence of HCC-3 differs from HCC-1 as follow: 27-27 R→ QTGGKPKVVKIQLKLVG. CCL14 was first isolated from the hemofiltrate of human patients with chronic renal failure. CCL14 promotes chemotaxis of T lymphocytes, monocytes and eosinophils, and inhibits infection of M-tropic human immunodeficiency virus type 1 and is a ligand for CCR1, CCR3 and CCR5. CCL14 is expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations in plasma. Recombinant human HCC-1/CCL14 is an 8.4kDa protein containing 72 amino-acid residues including the four highly conserved cysteine residues present in the CC chemokines.
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