Recombinant Human I-309/CCL1
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CAT.NO. : ARP6665
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Product Details
Background
Chemokine (C-C motif) ligand 1 (CCL1) belongs to a family inflammatory cytokine (also known as chemokines) . It is a small glycoprotein secreted by activated T cells with a molecular weight of approximately 8.5kDa. CCL1 signals through the CCR8 receptor. Human CCL1 has been assumed to be a homologue of the mouse TCA3. While the two proteins share only approximately 42% amino acid sequence identity, both chemokines contain an extra pair of cysteine residues not found in most other chemokines. Recombinant Human I-309 is an 8.6kDa protein consisting of 74 amino acid residues that include six cysteine residues, of which four are the highly conserved cysteine residues present in CC chemokines. Unlike some CC chemokines, whose biologically active form in solution is a non-disulfide-linked dimer, the biologically active form of I-309 is monomeric.
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