Recombinant Human Interleukin-12

Key features and details

  • Species: Human
  • Abbreviation: rHuIL-12
  • Source: Expressed in CHO.
  • Molecular Weight: Approximately 75.0 kDa, consisting of disulfide-linked 35.0 kDa (p35) and 40.0 kDa (p40) subunits.
  • Purity: >96% by SDS-PAGE or HPLC.
  • Endotoxin: < 0.01 EU/μg of rHuIL-12 protein as determined by LAL method.
  • Accession #: P29459 HuIL-12 p35: Arg23-Ser219; HuIL-12 p40: Ile23-Ser328
  • Storage:
  • Brand:
CAT.NO. : ARP6782
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Product Details
Background
IL-12 is a potent regulator of cell-mediated immune responses and it induces IFN-γ production by NK and T cells.  It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue-type mast cells.  Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells, and induces the development of IFN-γ-producing Th1 cells.  Recombinant Human IL-12 is a 75.0kDa heterodimeric glycoprotein consisting of disulfide-linked 35kDa (p35) and 40kDa (p40) subunits.
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