Recombinant Human Interleukin-22
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CAT.NO. : ARP6650
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Product Details
Background
IL-22 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. The human IL-22 gene is localized to chromosome 12q15. IL-22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (previously an orphan receptor named CRF2-9) and IL-10R beta (previously known as CRF2-4) , belonging to the class II cytokine receptor family. Mature human IL-22 protein shares approximately 79% aa sequence identity with mouse IL-22. Recombinant Human IL-22 is a 33.6kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains.
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