Recombinant Human Interleukin-8, 77a.a./CXCL8
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CAT.NO. : ARP6642
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Product Details
Background
Interleukin-8 (IL-8) is encoded by the IL8 gene and produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles. There are many receptors capable to bind IL-8, the most affinity to IL-8 are receptors CXCR1, and CXCR2. As a member of the CXC chemokine family, function of IL-8 is the induction of chemotaxis in its target cells, like neutrophil granulocytes, basophils, and T-cells. IL-8 is often associated with inflammation, it has been cited as a proinflammatory mediator in gingivitis and psoriasis. Mature human IL-8/CXCL8 shares 65%-69% amino acid sequence identity with canine, feline, and porcine IL-8/CXCL8. Recombinant Human IL-8 (CXCL8) (77a.a.) is an 8.9kDa protein containing 77 amino acid.
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