Recombinant Human Macrophage-Derived Chemokine/CCL22

Key features and details

  • Species: Human
  • Abbreviation: rHuMDC/CCL22
  • Source: Expressed in E. coli.
  • Molecular Weight: Approximately 8.1 kDa, a single non-glycosylated polypeptide chain containing 69 amino acids.
  • Purity: >97% by SDS-PAGE or HPLC.
  • Endotoxin: < 0.1 EU/μg of rHuMED/CCL22 protein as determined by LAL method.
  • Accession #: O00626 Gly25-Gln93
  • Storage:
  • Brand:
CAT.NO. : ARP6672
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Product Details
Background
CCL22 is a protein that in human is encoded by the CCL22 gene, which locates on the Chr. 16. The protein is highly expressed in macrophage, monocyte-derived dendritic cell and thymus, additionally, also detected in the tissues of thymus, lymph node and appendix. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells, and exerts HIV-suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity, but retains HIV-suppressive activity. Recombinant Human MDC is an 8.1kDa protein containing 69 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
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