Recombinant Human MCP-2/CCL8
CAT.NO. : ARP6787
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Background
Human CCL8, also known as monocyte chemotactic protein 2 (MCP-2) , is belonging to the CC chemokine family hat signal through CCR2 and, with the exception of MCP-1, other CCR receptors. It is encoded by the gene CCL8. MCP-2 has two homogeneous MCP-1 (CCL2) and MCP-3 (CCL7) . These three MCPs were found by IL-1- beta triggered human MG-63 osteosarcoma cells. CCL8 shares 62 % amino acid sequence identity with MCP-1, and shares 58 % amino acid sequence identity with MCP-2. CCL8 has chemotactic function for monocytes, eosinophils and neutrophils. In addition, it can also chemoattract activated NK cells but not monocytes or neutrophils. The MCP family cross-reacts across species. Recombinant Human MCP-2 (CCL8) is an 8.9kDa protein containing 76 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
