Recombinant Human MCP-2/CCL8

Key features and details

  • Species: Human
  • Abbreviation: rHuMCP-2/CCL8
  • Source: Expressed in E. coli.
  • Molecular Weight: Approximately 8.9 kDa, a single non-glycosylated polypeptide chain containing 76 amino acids.
  • Purity: >97% by SDS-PAGE or HPLC.
  • Endotoxin: < 0.01 EU/μg of of rHuMCP-2/CCL8 protein as determined by LAL method.
  • Accession #: P80075 Gln24-Pro99
  • Storage:
  • Brand:
CAT.NO. : ARP6787
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Product Details
Background
Human CCL8, also known as monocyte chemotactic protein 2 (MCP-2) , is belonging to the CC chemokine family hat signal through CCR2 and, with the exception of MCP-1, other CCR receptors. It is encoded by the gene CCL8. MCP-2 has two homogeneous MCP-1 (CCL2) and MCP-3 (CCL7) . These three MCPs were found by IL-1- beta triggered human MG-63 osteosarcoma cells. CCL8 shares 62 % amino acid sequence identity with MCP-1, and shares 58 % amino acid sequence identity with MCP-2. CCL8 has chemotactic function for monocytes, eosinophils and neutrophils. In addition, it can also chemoattract activated NK cells but not monocytes or neutrophils. The MCP family cross-reacts across species. Recombinant Human MCP-2 (CCL8) is an 8.9kDa protein containing 76 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
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