Recombinant Human Monocyte Chemotactic Protein-4/CCL13

Key features and details

Species: Human
Abbreviation: rHuMCP-4/CCL13
Source: Expressed in E. coli.
Molecular Weight: Approximately 8.6 kDa, a single non-glycosylated polypeptide chain containing 75 amino acids.
Purity: ＞96% by SDS-PAGE or HPLC.
Endotoxin: < 0.1 EU/μg of rHuMCP-4/CCL13 protein as determined by LAL method.
Accession #: Q99616 Gln24-Thr98
Storage:

Brand:

CAT.NO. : ARP6669

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Size:

50μg

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Product Details

Background

Human CCL13 is belonging to the CC chemokine family and is encoded by the gene CCL13 in humans. CCL13 (MCP-4) shares 56-61% sequence identity with MCP-1 (CCL2) and MCP-3 (CCL7) and is 60% identical to Eotaxin (CCL11) . CCL13 was a potent chemoattractant for monocytes and eosinophils and stimulated histamine release from basophils. CCL13 can induce a calcium flux in HEK-293 cells transfected with the receptor CCR2B and CCR3. That shows the function receptors of CCL3 are CCR2B and CCR3. Recombinant human MCP-4/CCL13 is an 8.6kDa protein containing 75 amino-acid residues including the four highly conserved cysteine residues present in the CC chemokines.

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