Recombinant Human Novel Neurtrophin-1/B-Cell Stimulating Factor-3
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CAT.NO. : ARP6708
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Product Details
Background
Novel Neurotrophin-1 (NNT-1) or B-Cell Stimulating Factor-3 (BSF-3) , is a new member of the IL-6 family of structurally related cytokines that includes IL-6, CNTF, LIF, CT-1, IL-11 and OSM. All family members share the receptor subunit gp130 that belong to the type I cytokine receptor superfamily. Ligand binding leads to gp130 homodimerization or heterodimerization (with LIF receptor or OSM receptor beta) , and induces cell signaling and functional activity. For several family members, including CNTF, IL-6, and IL-11, binding of the ligand to a specific receptor alpha subunit (CNTF R alpha, IL-6 R alpha, or IL-11 R alpha) is required prior to gp130 homo- or hetero-dimerization. Recombinant human NNT-1/BCSF-3 a 22.3kDa protein containing 198 amino-acid residues.
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