Recombinant Human Parathyroid Hormone 7-34
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CAT.NO. : ARP6763
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Product Details
Background
Parathyroid hormone (PTH) is a single polypeptide of 84 amino acids. PTH is a critical hormone in the regulation of Ca2+ homeostasis. PTH is secreted by the parathyroid glands, which promote release of calcium from bone to extracellular fluid by activating osteoblasts and inhibiting osteoclasts, indirectly promote increased intestinal absorption of calcium, and promote renal tubular reabsorption of calcium and increased renal excretion of phosphates. It is a major regulator of bone metabolism. Secretion of parathyroid hormone increases when the level of calcium in the extracellular fluid is low. PTH (7-34) , which is a PTH/PTHrP receptor antagonist, can stimulate hair growth and epidermal proliferation in mice. Recombinant PTH7-34 is a 3.4kDa protein containing 28 amino acid residues.
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