Recombinant Human Stromal-Cell Derived Factor-1 beta/CXCL12 alpha
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CAT.NO. : ARP6683
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Background
CXCL12 also known as SDF-1 is belonging to the CXC chemokine family. It is encoded by the CXCL12 gene. In recently study, Human CXCL12 is expressed as six isoforms that differ only in the C-terminal tail. And all SDF-1 isoforms undergo proteolytic processing of the first two N-terminal amino acids. In all SDF-1 isoforms, SDF-1β is the canonical sequence. Contrast to the canonical sequence SDF-1β, SDF-1α is shorter by four amino acids at the C-terminal tail. On the cell surface, the receptor for this chemokine is CXCR4 and syndecan 4. CXCL12 is strongly chemotactic for T-lymphocytes, monocytes, but not neutrophils. CXCL12 is a very important factor in carcinogenesis and the neovascularization linked to tumor progression. Recombinant human Stromal-Cell Derived Factor-1 alpha/CXCL12 alpha is an 8.0kDa protein containing 68 amino acid residues.
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