Recombinant Human Tau (acetyl K281) Protein
Key features and details
- Product Name:
- Expression Systems:
- Species:
- Formulation:
-
Brand:
CAT.NO. : AXP6625
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Size:
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Product Details
Background
Tau (acetyl K281) refers to the tau protein with an acetyl group added (acetylated) at Lysine 281 (K281), a specific post-translational modification heavily implicated in Alzheimer's Disease (AD) and other tauopathies, which disrupts tau's normal function, promotes synaptic dysfunction, impairs memory, destabilizes microtubules, and enhances toxic tau aggregation. Acetylation at K281 (often with K274/K280) is a key pathological event, leading to loss of microtubule binding, accumulation of tau tangles, and cognitive decline.
Overview
|
Protein name |
Microtubule-associated protein tau |
|
Gene name |
MAPT |
|
Organism |
Homo sapiens (Human) |
|
Product name |
Recombinant Human Tau (acetyl K281) Protein |
|
Predicted molecular mass |
48 kDa |
|
Expression host |
Escherichia coli |
|
Modification |
Acetylation |
|
Purification tag |
6xHis at C-terminus |
|
Usage |
This product is validated for use as an immunogen and as a reagent in immunological assays |
|
Form |
Liquid |
|
Buffer |
Phosphate buffered saline |
Storage
Shipped on dry ice. Avoid repeated freeze-thaw cycles.
Upon receipt,
* 2 days when stored at 2 to 8 °C
* 12 months when aliquoted and stored at -20 °C or below
Upon receipt,
* 2 days when stored at 2 to 8 °C
* 12 months when aliquoted and stored at -20 °C or below
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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