Recombinant Murine Cerebral Dopamine Neurotrophic Factor
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CAT.NO. : ARP6712
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Background
Cerebral dopamine neurotrophic factor (CDNF) , also known as ARMET-like protein 1, is a protein encoded by the CDNF gene and it is widely expressed in neuronal and non-neuronal tissues. The cerebral dopamine neurotrophic factor (CDNF) also is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF) . By research, CDNF prevents the 6-hydroxydopamine (6-OHDA) -induced degeneration of dopaminergic neurons and it might be beneficial for the treatment of Parkinson’s disease. Murine CDNF shares 81% and 87% a.a. sequence identity with human and rat CDNF. Recombinant murine CDNF is an 18.5kDa protein containing 163 amino-acid residues.
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