Recombinant Murine Sonic Hedgehog
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CAT.NO. : ARP6710
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Product Details
Background
Sonic hedgehog is one of three proteins in the mammalian signaling pathway family called hedgehog, the others being desert hedgehog (DHH) and Indian hedgehog (IHH) . As the hh homologues, SHH has been found to have the most critical roles in development. It acts as a morphogen involved in patterning many systems, including the limb and midline structures in the brain, spinal cord, the thalamus by the zona limitans intrathalamica and the teeth. There SHH undergoes auto-processing to generate a 20kDa N-terminal signaling domain (SHH-N) and a 25kDa C-terminal domain with no known signaling role. Recombinant Murine Sonic Hedgehog is a 20.0kDa protein consisting of 176 amino acid residues, including an N-terminal Ile-Val-Ile sequence substituted for the naturally occurring, chemically modified Cys residue.
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