Recombinant Rat Cerebral Dopamine Neurotrophic Factor

Key features and details

  • Species: Rat
  • Abbreviation: rRtCDNF
  • Source: Expressed in E. coli.
  • Molecular Weight: Approximately 18.8 kDa, a single non-glycosylated polypeptide chain containing 163 amino acids.
  • Purity: >96% by SDS-PAGE or HPLC.
  • Endotoxin: < 0.1 EU/μg of rRtCDNF protein as determined by LAL method.
  • Accession #: P0C5I0 Gln25-Leu187
  • Storage:
  • Brand:
CAT.NO. : ARP6713
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Product Details
Background
Cerebral dopamine neurotrophic factor (CDNF) , also known as ARMET-like protein 1, is a protein encoded by the CDNF gene and it is widely expressed in neuronal and non-neuronal tissues. The cerebral dopamine neurotrophic factor (CDNF) also is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF) . By research, CDNF prevents the 6-hydroxydopamine (6-OHDA) -induced degeneration of dopaminergic neurons and it might be beneficial for the treatment of Parkinson’s disease. Rat CDNF shares 83% and 87% a.a. sequence identity with human and murine CDNF. Recombinant rat CDNF is an 18.8kDa protein containing 163 amino-acid residues.
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