Recombinant Rat Ciliary Neurotrophic Factor
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CAT.NO. : ARP6688
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Background
Ciliary neurotrophic factor (CNTF) is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. CNTF was initially identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture. Furthermore, the protein is also a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. In addition, CNTF is useful for treatment of motor neuron disease and it could reduce food intake without causing hunger or stress. Rat CNTF shares 83% and 95% a.a. sequence identity with human and murine CNTF. Recombinant rat CNTF is a 22.7kDa globular protein containing 199 amino acid.
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