RIPK1 Rabbit Monoclonal Antibody(YJY-4-3)
Key features and details
- Reactivity:Mouse
- Application:WB, IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:RIPK1
-
Brand:
CAT.NO. : ARA6603
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Size:
Trail, Bulk size or Custom requests Please contact us
Product Details
Background
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor (By similarity). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (By similarity).
Application
|
Application |
Dilution Ratio |
|
WB |
1:10 - 1:100 |
|
IHC |
1:10 - 1:100 |
Overview
|
Predicted Molecular Weight |
75kDa |
|
Species Cross-reactivity |
Mouse (Species cross-reactivity determined by WB) |
|
Purity |
ProA affinity purified IgG |
|
Form |
Liquid |
|
Swissprot ID |
Q60855 |
|
Immunogen |
A synthetic peptide corresponding to residues aa100-200 of mouse RIPK1 was used as an immunogen. |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. |
Data
All lanes: RIPK1 Rabbit Monoclonal Antibody(YJY-4-3) at 1:100 dilution
Predicted MW: 75 kDa
Observed MW: 70 kDa
Lane 1: WT RIPK1 MEFs
Lane 2: RIPK1 KO MEFs
Lysates at approx. 10 μg per lane
2nd Ab: GAR HRP(H+L) 1:4,000
Exposure: 30s
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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