RRM1 Rabbit Monoclonal Antibody(ARB540)

Key features and details

Target: RRM1
Clone ID: ARB540
Host: Rabbit
Molecular Weight: 90 kDa
Purity: ProA affinity purified IgG
Species Cross-reactivity: Human
Applications: IHC-P
Swissprot ID: P23921

Brand:

CAT.NO. : ARB6832

RMB Please choose

Size:

1mL

Trail, Bulk size or Custom requests Please contact us

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Product Details

Background

Ribonucleotide reductase M1 polypeptide (RRM1) is one of two non - identical subunits for ribonucleoside - diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated in quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the response of non - small - cell lung cancer (NSCLC) to chemotherapy.

Application

Application	Dilution Ratio
IHC	1:100-1:200

Overview

Target	RRM1
Host Species	rabbit monoclonal antibody
Molecular Weight	90 kDa
Purity	ProA affinity purified IgG
Species Cross-reactivity	Human
Form	Liquid
Applications	IHC-P
Swissprot ID	P23921
Immunogen	Synthetic peptide corresponding to residues within aa700-800 of Human RRM1
Storage Buffer	PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%
Storage Conditions	-25°C to -18°C
Dilutions	IHC-P: 1:100-1:200
Subcellular Location	Cytoplasmic
Recommended Method	Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes