S100 Rabbit Monoclonal Antibody(ARA945)
Key features and details
- Reactivity:Human
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:S100
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Brand:
CAT.NO. : ARA6786
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Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
The family of EF-hand type Ca2+-binding proteins includes calbindin (previously designated vitamin D-dependent Ca2+-binding protein), S-100 α and β, calgranulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins), and the parvalbumin family members, including parvalbumin α and parvalbumin β (also designated oncomodulin). The S-100 protein is involved in the regulation of cellular processes such as cell cycle progression and differentiation. Research also indicates that the S-100 protein may function in the activation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly and inhibition of protein kinase C mediated phosphorylation. Two S-100 subunits, sharing 60% sequence identity, have been described as S-100 α chain and S-100 β chain. Three S-100 dimeric forms have been characterized, differing in their subunit composition of either two α chains, two β chains or one α and one β chain. S-100 localizes to the cytoplasm and nuclei of astrocytes, Schwann's cells, ependymomas and astrogliomas. S-100 is also detected in almost all benign naevi, malignant melanocytic tumours and in Langerhans cells in the skin. Calbindin, S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S-100 α and β are present in a variety of other tissues, and calbindin is present in intestine and kidney.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:200-1:1,000 |
Overview
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Antibody Type |
Recombinant Rabbit Monoclonal Antibody |
|
Immunogen |
Recombinant full length protein of mouse S100 an 1-94 / 94 |
|
Species Reactivity |
Human, Mouse, Rat |
|
Validated Applications |
WB, IP, IHC-P, FC, IF-Cell |
|
Molecular Weight |
Predicted band size: 11 kDa |
|
Positive Control |
Mouse heart tissue lysate, Mouse kidney tissue lysate, Mouse brain tissue lysate, human appendix tissue, human kidney tissue, human brain tissue, mouse brain tissue, rat brain tissue, RAW264.7 |
|
Conjugation |
unconjugated |
|
Clone Number |
JM51-31 |
|
Form |
Liquid |
|
Concentration |
1μg/ul |
|
Storage Buffer |
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical staining of human appendix tissue using S100 Rabbit Monoclonal Antibody(ARA945)
Immunohistochemical staining of human kidney tissue using S100 Rabbit Monoclonal Antibody(ARA945)
Immunohistochemical staining of human brain tissue using S100 Rabbit Monoclonal Antibody(ARA945)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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