SC Mouse Monoclonal Antibody(ARA987)
Key features and details
- Reactivity:Human, Mouse, Rat
- Application:IHC
- Host:Mouse
- Clonality:Monoclonal
- lsotype:IgG1k
- Target:SC
-
Brand:
CAT.NO. : ARA6872
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。
Product Details
Background
Polymeric IgA and IgM is produced and secreted by B cells in the lamina propria, which is beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors, also designated pIgRs, are expressed on the basolateral surface of glandular epithelium and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium. pIgR associates with secreted dimeric IgA and IgM molecules. During transcellular transport of these Ig polymers, pIgR undergoes proteolytic cleavage to generate a fragment called secretory component (SC), polymeric immunoglobulin receptor or poly-Ig receptor. When immunoglobulin polymers associate with SC, they become resistant to enzymatic degradation during the transcytosis process. SC and the pIgR are crucial for proper mucosal immunity, where they represent a molecular chaperone for polymeric Igs to remain intact and enter into body fluids. The human SC (pIgR) gene maps to chromosome 1q32.1 and encodes a 764 amino acid protein. The receptor contains five units with homology to the variable (V) units of immunoglobulins and a transmembrane region that shares homology to certain immunoglobulin variable regions.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:50 - 1:500 |
Overview
|
Clonality |
Monoclonal Antibody |
|
Isotype |
IgG₁ kappa light chain |
|
Amino Acids |
465-764 |
|
Epitope Target |
SC |
|
Epitope Species |
human |
|
Product Reactivity/Assay |
SC |
|
Species Reactivity/Assay |
mouse, rat, human |
|
Applications |
IHC |
Data
Immunohistochemical staining of human gallbladder tissue sections using SC Mouse Monoclonal Antibody (ARA987).
Immunohistochemical staining of human cervical tissue sections using SC Mouse Monoclonal Antibody (ARA987).
Storage
Store at +4℃ after thawing. DO NOT FREEZE. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
New Products
