SDHB Rabbit Monoclonal Antibody(ARA951)
Key features and details
- Reactivity:Human
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:SDHB
-
Brand:
CAT.NO. : ARA6793
RMB Please choose
RMB Please choose
Product Details
Background
In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations associate with juvenile encephalopathy as well as Leigh syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:200-1:1000 |
Overview
|
Antibody Type |
Recombinant Rabbit Monoclonal Antibody |
|
Immunogen |
Synthetic peptide within Human 50MB aa 201 - 250 / 280 |
|
Species Reactivity |
Human, Mouse, Rat |
|
Validated Applications |
WB, IHC-P |
|
Molecular Weight |
Predicted band size: 32 kDa |
|
Positive Control |
HepG2 cell lysate, Mouse spleen tissue lysate, Rat spleen tissue lysate, Rat liver tissue lysate, Human liver tissue lysate, human kidney tissue, mouse kidney tissue, rat kidney tissue, human liver tissue, human colon carcinoma tissue |
|
Conjugation |
unconjugated |
|
Form |
Liquid |
|
Concentration |
1μg/ul |
|
Storage Buffer |
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical staining of human kidney tissue using SDHB Rabbit Monoclonal Antibody(ARA951)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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