SHP Rabbit Polyclonal Antibody
Key features and details
- Reactivity:Human, Mouse, Rat
- Application:WB
- Host:Rabbit
- Clonality:Polyclonal
- Target:SHP
-
Brand:
CAT.NO. : ARA6803
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Product Details
Background
Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways.Specifically inhibits transactivation of the nuclear receptor with which it interacts.Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1.Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity).Regulates the circadian expression of cytochrome P450 (CYP) enzymes.
Application
|
Application |
Dilution Ratio |
|
WB |
1:500 - 1:1000 |
Overview
|
Immunogen |
Recombinant full length protein of human SHP |
|
Purification Method |
The antibody was purified by immunogen affinity chromatography |
|
Clonality |
Polyclonal |
|
Form |
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide |
|
Gene Name |
NR0B2 |
|
Synonyms |
SHP; Nuclear receptor subfamily 0 group B member 2; Orphan nuclear receptor SHP; Small heterodimer partner |
|
Gene ID (Human) |
8431 |
|
Gene ID (Mouse) |
23957 |
|
Gene ID (Rat) |
117274 |
|
Protein ID (Human) |
Q15466 |
|
Protein ID (Mouse) |
Q62227 |
Data
Western blot analysis of SHP expression in mouse liver (A), mouse kidney (B) whole cell lysates. (Predicted band size: 28 kD; Observed band size: 28 kD)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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