SLC45A3 Rabbit Monoclonal Antibody(ARA937)

Key features and details

Reactivity:Human
Application:IHC
Host:Rabbit
Clonality:Monoclonal
Target:SLC45A3

Brand:

CAT.NO. : ARA6775

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Size:

1mL 100μL

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Product Details

Background

Solute carrier family 45 member 3 (SLC45A3), also known as prostate cancer-associated protein 6 or prostein, is a protein that in humans is encoded by the SLC45A3 gene. SLC45A3 is an androgen-regulated gene and a prostate specific marker expressed in prostatic glandular cells. SLC45A3 is the second most common gene fusion partner in prostate cancers. SLC45A3-ERG and SLC45A3-ELK4 fusion transcripts have been detected in prostate cancer. Loss of prostein expression in SLC45A3-ERG tumors are significantly associated with high Gleason scores and poor clinical outcomes. Prostein immunoreactivity is seen in the majority of primary and metastatic prostate carcinomas. Staining for prostein in conjunction with PSA improves identification of prostatic origin in unknown primary lesions, when compared against prostein or PSA staining alone.

Application

Application	Dilution Ratio
IHC-P	1:50-1:200

Overview

Antibody Type	Recombinant Rabbit Monoclonal Antibody
Immunogen	Synthetic peptide within Human SLC45A3 aa 400 - 500
Species Reactivity	Human
Validated Applications	IHC-P, IF-Tissue
Molecular Weight	Predicted band size: 59 kDa
Positive Control	Human prostate tissue, human prostate cancer tissue
Conjugation	unconjugated
Form	Liquid
Concentration	1μg/μl
Storage Buffer	1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide
Isotype	IgG
Purification Method	Protein A affinity purified