SOX-11 Rabbit Monoclonal Antibody(ARB862)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6654
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Product Details
Background
SOX11 (SOX = SRY-related HMG box) is a nuclear transcription factor belonging to subgroup C of SRY (sex determining region on Y-chromosome) related HMG (high mobility group) box genes. It contains 2 functional domains: A HMG box DNA-binding domain, located at the N-terminus, and a transactivation domain (TAD), located at the C-terminus.
SOX11 expression is critical for embryonic neurogenesis and tissue remodeling, it is normally expressed during the developing nervous system of human embryos and is required for neurite growth and neuron survival. Expression is seen in fetal tissues (18-25 weeks) mainly in the brain. Outside the CNS SOX11 seems primarily to be expressed at sites of epithelial-mesenchymal interactions. SOX11 is not expressed in normal adult human tissues, and its over-expression is reported in over 90% of mantle cell lymphomas (MCL), including the rare cyclin D1 negative cases.
Currently the only diagnostic application is verification of mantle cell lymphomas, particularly the rare cyclin D1 negative cases.
SOX11 expression is critical for embryonic neurogenesis and tissue remodeling, it is normally expressed during the developing nervous system of human embryos and is required for neurite growth and neuron survival. Expression is seen in fetal tissues (18-25 weeks) mainly in the brain. Outside the CNS SOX11 seems primarily to be expressed at sites of epithelial-mesenchymal interactions. SOX11 is not expressed in normal adult human tissues, and its over-expression is reported in over 90% of mantle cell lymphomas (MCL), including the rare cyclin D1 negative cases.
Currently the only diagnostic application is verification of mantle cell lymphomas, particularly the rare cyclin D1 negative cases.
Overview
| Target | SOX11 |
| Host Species | rabbit monoclonal antibody |
| Molecular Weight | 47 kDa |
| Purity | ProA affinity purified IgG |
| Species Cross-reactivity | Human |
| Form | Liquid |
| Applications | IHC-P |
| Swissprot ID | P35716 |
| Immunogen | Synthetic peptide corresponding to SOX11 residues within aa300-400 |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
| Storage Conditions | -25°C to -18°C |
| Dilutions | IHC-P: 1:100-1:200 |
| Subcellular Location | Nucleus |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes |
Data
Immunohistochemical staining of human mantle cell lymphoma (MCL) tissue sections using SOX-11 Rabbit Monoclonal Antibody (ARB862).
Immunohistochemical staining of human mantle cell lymphoma (MCL) tissue sections using SOX-11 Rabbit Monoclonal Antibody (ARB862).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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