Survivin Rabbit Monoclonal Antibody(ARB555)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6847
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。
Product Details
Background
Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy. Survivin binds and inhibits caspase-3, controlling the checkpoint in the G2/M-phase of the cell cycle by inhibiting apoptosis and promoting cell division. This regulatory process requires the phosphorylation of survivin at Thr34 by p34 cdc2 kinase. Gene targeting using a Thr34 phosphorylation-defective survivin mutant, as well as antisense survivin, have been shown to inhibit tumor growth.
Survivin is expressed in tonsil, testis, fetal tissue and all kinds of tumors. Survivin is not thought to be expressed in adult terminally differentiated cells, but recent evidence has also shown expression on adult vascular endothelial cells, T cells, red blood cells, and hematopoietic progenitor cells.
Survivin is mainly used in the diagnosis of hepatocellular carcinoma, endometrial carcinoma and squamous cell carcinoma.
Survivin is expressed in tonsil, testis, fetal tissue and all kinds of tumors. Survivin is not thought to be expressed in adult terminally differentiated cells, but recent evidence has also shown expression on adult vascular endothelial cells, T cells, red blood cells, and hematopoietic progenitor cells.
Survivin is mainly used in the diagnosis of hepatocellular carcinoma, endometrial carcinoma and squamous cell carcinoma.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:200 |
Overview
|
Predicted Molecular Wt |
16kDa |
|
Species Cross-reactivity |
Human |
|
Applications |
IHC-P |
|
Purity |
ProA affinity purified IgG |
|
Form |
Liquid |
|
Swissprot ID |
O15392 |
|
Subcellular location |
Nucleus |
|
Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
Data
Immunohistochemical staining of human tonsil tissue using Survivin Rabbit Monoclonal Antibody(ARB555)
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
New Products
