Tau Mouse Monoclonal Antibody(ARM573)

Key features and details

Target: Tau
Clone ID: ARM573
Host Species: Mouse
Species Cross-reactivity: Human
Applications: IHC-P
Dilution: 1:100-1:200
Clonality: Monoclonal

Brand:

CAT.NO. : ARM6863

RMB Please choose

Size:

1mL

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Product Details

Background

Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Application

Application	Dilution Ratio
IHC	1:100 - 1:200

Overview

Molecular Weight	19,593 Da
Isotype	IgG
Host	Mouse
Species Reactivity	Human
Form/Format	Liquid
Buffer	Tris Buffer, ph7.4, 1% BSA, <0.1% NaN3
IHC Positive Control	Thyroid