Tau (S305) Mouse Monoclonal Antibody(ARA975)
Key features and details
- Reactivity:Human
- Application:ELISA
- Host:Mouse
- Clonality:Monoclonal
- Target:Tau (S305)
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Brand:
CAT.NO. : ARA6841
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Product Details
Background
Tau (S305) refers to a specific site on the tau protein, where a mutation in the S305N form is associated with a form of frontotemporal dementia. Research shows that phosphorylation at the S305 site normally inhibits tau aggregation, a process linked to neurodegenerative diseases like Alzheimer's and frontotemporal dementia. Mutations at this site, such as S305N, increase the proportion of a specific tau isoform (4R) and can disrupt normal brain cell function.
Overview
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Antibody Specificity |
Recognizing Tau protein containing S305 and S356 peptides that share a sequence of HVPGGG |
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Species Reactivity |
Human |
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Clonality |
Monoclonal |
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Host / Isotype |
Mouse / IgG2a |
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Immunogen |
Recombinant human Tau (phospho) |
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Cross Reactivity |
Not tested |
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Recombinant |
Not recombinant |
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Purification |
Protein A purification |
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Form |
Liquid |
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Conjugation |
Unconjugated |
Data
Epitope analysis of Tau (S305) by ARA6841 by ELISA.
Synthetic peptides containing indicated residues were coated onto microtiter wells. Recombinant Tau (2-244), Tau (1-368), Tau (243-368) and Tau (1-441) proteins with isoform P10636-8 or Tau (1-758) (with isoform P10636-1) were also coated. The antibody ARA6841 was applied as the primary antibody. Peroxidase-conjugated goat anti-mouse IgG was used as the secondary antibody, and signals were detected using a colorimetric assay.
Result: ARA6841 recognizes Tau protein containing S305 and S356 peptides that share a sequence of HVPGGG.
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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