Tau (S305) Mouse Monoclonal Antibody(ARA977)
Key features and details
- Reactivity:Human
- Application:ELISA
- Host:Mouse
- Clonality:Monoclonal
- Target:Tau (S305)
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Brand:
CAT.NO. : ARA6843
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Product Details
Background
Tau (S305) refers to a specific site on the tau protein, where a mutation in the S305N form is associated with a form of frontotemporal dementia. Research shows that phosphorylation at the S305 site normally inhibits tau aggregation, a process linked to neurodegenerative diseases like Alzheimer's and frontotemporal dementia. Mutations at this site, such as S305N, increase the proportion of a specific tau isoform (4R) and can disrupt normal brain cell function.
Overview
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Antibody specificity |
Recognizing Tau protein containing S305 and S356 peptides that share a sequence of HVPGGG |
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Species reactivity |
Human |
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Clonality |
Monoclonal |
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Host / isotype |
Mouse / IgG2b |
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Immunogen |
Recombinant human Tau (phospho) |
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Cross reactivity |
Not tested |
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Recombinant |
Not recombinant |
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Purification |
Protein A purification |
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Form |
Liquid |
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Conjugation |
Unconjugated |
Data
Sandwich ELISA analysis of Tau (S305) by ARA6843 & ARA6840.
Microtiter plates were coated with ARA6840 as the capture antibody. Recommbinant pTau217 protein (AXP6612) was applied as the antigen. Peroxidase conjugated pTau217 Antibody (ARA6843) served as the detection antibody.
Result: ARA6843 and ARA6840 can be used as a matched antibody pair to detect and quantify the concentration of pTau217 .
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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