Tau (S422) Mouse Monoclonal Antibody(ARA958)
Key features and details
- Reactivity:Human
- Application:Sandwich ELISA
- Host:Mouse
- Clonality:Monoclonal
- lsotype:IgG2a
- Target:Tau (S422)
-
Brand:
CAT.NO. : ARA6807
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Product Details
Background
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Application
|
Application |
Dilution Ratio |
|
WB |
1:200 - 1:1000 |
|
Sandwich ELISA |
1:250 - 1:500 |
|
IHC-P |
1:250 - 1:500 |
Overview
|
Species Reactivity |
Human, Mouse |
|
Clonality |
Monoclonal |
|
Host / Isotype |
Mouse / IgG2a |
|
Immunogen |
Recombinant human Tau (phospho) |
|
Cross Reactivity |
Not tested |
|
Recombinant |
Not recombinant |
|
Purification |
Protein A purification |
|
Form |
Liquid |
|
Conjugation |
Unconjugated |
Data
Western blotting analysis of Tau (S422)
Immunohistochemical staining of brain tissue sections using Tau (S422) Mouse Monoclonal Antibody (ARA958).
Sandwich ELISA analysis of Tau (S422)
Epitope analysis of Tau (S422) by ELISA.
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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