Tau (T17) Mouse Monoclonal Antibody(ARA979)
Key features and details
- Reactivity:Human
- Application:ELISA
- Host:Mouse
- Clonality:Monoclonal
- Target:Tau (T17)
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Brand:
CAT.NO. : ARA6845
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Product Details
Background
Plasma p-tau217 is a biomarker associated with Alzheimer's disease (AD) pathology. Research has shown that plasma p-tau217 is a sensitive marker of the clinical manifestation and progression of AD, including amyloid accumulation, tau burden, brain atrophy, and physical degradation. It has been found to be a potential non-invasive biomarker of AD, with high diagnostic accuracy in differentiating AD from other neurodegenerative diseases. Plasma p-tau217 has also been associated with longitudinal increases in Aβ PET uptake and cognitive decline in Aβ-positive clinically unimpaired individuals. Additionally, higher baseline p-tau217 levels have been linked to greater future tau PET pathology burden and worse future memory performance. These findings suggest that plasma p-tau217 could serve as a minimally invasive diagnostic and prognostic biomarker for AD, with potential utility in clinical practice and trials.
Application
|
Application |
Dilution Ratio |
|
ELISA |
1:250 - 1:500 |
Overview
|
Antibody specificity |
Recognizing Tau protein with an epitope within 20 residues around T17 |
|
Species reactivity |
Human |
|
Clonality |
Monoclonal |
|
Host / isotype |
Mouse / IgG2b |
|
Immunogen |
Recombinant human Tau (phospho) |
|
Cross reactivity |
Not tested |
|
Recombinant |
Not recombinant |
|
Purification |
Protein A purification |
|
Form |
Liquid |
|
Conjugation |
Unconjugated |
Data
Sandwich ELISA analysis of Tau (T17) by ARA6845 & ARA6837.
Microtiter plates were coated with ARA6845 as the capture antibody. Recommbinant Tau protein (AXP6617) was applied as the antigen. Peroxidase conjugated Tau (T17) Antibody (ARA6837) served as the detection antibody.
Result: ARA6845 and ARA6837 can be used as a matched antibody pair to detect and quantify the concentration of Tau.
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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