TCR beta F1 Mouse Monoclonal Antibody(ARA986)
Key features and details
- Reactivity:Mouse, Primates, Human
- Application:WB, IP, IHC, ICC/IF
- Host:Mouse
- Clonality:Monoclonal
- lsotype:IgG1
- Target:TCR beta F1
-
Brand:
CAT.NO. : ARA6871
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Size:
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Product Details
Background
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed : 24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed : 25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed : 23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity .
Application
|
Application |
Dilution Ratio |
|
IHC |
1:50 - 1:200 |
Overview
|
Host Species |
Mouse |
|
Clonality |
Monoclonal |
|
Isotype |
IgG1 |
|
Species Reactivity |
Human, Mouse, Primates |
|
Applications |
WB, Flow Cyt, IP, IHC-P, ICC/IF |
|
Immunogen |
Full Length Protein corresponding to Human TRBV7-9. The exact immunogen used to generate this antibody is proprietary information. |
|
Form |
Liquid |
|
Purification Process |
Affinity purification Protein G |
|
Storage Solution |
Preservative: 0.1% Sodium azide; Constituents: PBS, 0.5% BSA |
Data
Immunohistochemical staining of thymoma tissue sections using TCR beta F1 Mouse Monoclonal Antibody (ARA986).
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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