TIFA Rabbit Polyclonal Antibody

Key features and details

Reactivity:Human, Mouse, Rat
Application:WB
Host:Rabbit
Clonality:polyclonal
Target:TIFA

Brand:

CAT.NO. : ARA6423

RMB Please choose

Size:

100μL 50μL

Trail, Bulk size or Custom requests Please contact us

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

Background

TIFA (TRAF-interacting protein with FHA domain-containing protein A ), also called T2BP, can interact with TRAF6 and plays an important role in innate immunity (PMID: 32910997; 35635239). Oligomerization of TIFA, which induces oligomerization and polyubiquitinylation of TRAF6, in turn activates TAK and IKK, finally mediates NF‐κB activation in the Toll‐like receptor 4/interleukin‐1 signaling pathway (PMID: 15492226; 22566686). It has been reported that TIFA also plays various roles in different cancer types (PMID: 26501855; 29263897).

Application

Application	Dilution Ratio
WB	1:500 - 1:2000

Overview

Composition	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity	This antibody detects endogenous levels of TIFA in Human, Mouse, Rat.
Purification Process	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration	1 mg/mL
Theoretical Molecular Weight	20 kDa
Modification	Unmodified
Clonality	Polyclonal
Isotype	IgG
Immunogen	Synthesized peptide derived from human TIFA
Gene Symbol	TIFA, T2BP
Protein Name	TIFA
Alternative Names	TRAF-interacting protein with FHA domain-containing protein A; Putative MAPK-activating protein PM14; Putative NF-kappa-B-activating protein 20
SwissProt ID (Human)	Q96CG3
SwissProt ID (Mouse)	Q79318
SwissProt ID (Rat)	Q5XIB9
Subcellular Localization	Cytoplasm. Colocalizes with lysosomal marker LAMP2 following homooligomerization and subsequent activation.