Tn Antigen Antibody Duo (sTn, Tn)

产品描述: The first step in O-linked oligosaccharide synthesis is adding a N-acetylgalactosamine to serine or threonine resulting in the formation of the Tn antigen and Tn antigen can be proceed along different pathways through different glycosylation processes. The additional sialic acid by an α2,6-sialyltransferase forms the sialosyl-Tn antigen (SAα2,6GalNAcα-O-Ser/Thr), moreover, the sialosyl-Tn antigen might not apparently undergo further glycosylation. Both antigens have been shown previously to be highly sensitive and specific markers of various cancer types including colorectal cancer. The abnormal protein glycosylation might associated with human cancer and the identification of protein glycoforms might be cancer biomarkers and therapeutic targets. In addition, the Tn antigen is also expressed by the protein gp120 of the human immunodeficiency virus (HIV), and in a wide range of helminth parasites. arigo provides a Tn antigen antibody Duos, ARG30015, including antibodies reacting Tn antigen and Sialosyl-Tn antigen for users to study the potentially glycol-structure of the target protein in cancer or infectious area and it might be useful to findout the biomarker and therapeutic agent.
靶点名称: Tn Antigen
別名: Tn Antigen antibody; Tn antigen antibody; Sialyl Tn antibody

CAT.NO. : ARG30015

US＄ Please choose

Size:

1 pair

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Product Details

内含物

货号	内含物名称	宿主克隆性	反应	应用	包装
ARG53971	anti-Sialyl Tn antibody [STn 219]	Mouse mAb	Hu	FACS, ICC/IF, IHC	250 μl
ARG53970	anti-Tn antigen antibody [Tn 218]	Mouse mAb	Hu	ICC/IF, IHC	250 μl

概述

产品描述	The first step in O-linked oligosaccharide synthesis is adding a N-acetylgalactosamine to serine or threonine resulting in the formation of the Tn antigen and Tn antigen can be proceed along different pathways through different glycosylation processes. The additional sialic acid by an α2,6-sialyltransferase forms the sialosyl-Tn antigen (SAα2,6GalNAcα-O-Ser/Thr), moreover, the sialosyl-Tn antigen might not apparently undergo further glycosylation. Both antigens have been shown previously to be highly sensitive and specific markers of various cancer types including colorectal cancer. The abnormal protein glycosylation might associated with human cancer and the identification of protein glycoforms might be cancer biomarkers and therapeutic targets. In addition, the Tn antigen is also expressed by the protein gp120 of the human immunodeficiency virus (HIV), and in a wide range of helminth parasites. arigo provides a Tn antigen antibody Duos, ARG30015, including antibodies reacting Tn antigen and Sialosyl-Tn antigen for users to study the potentially glycol-structure of the target protein in cancer or infectious area and it might be useful to findout the biomarker and therapeutic agent.
靶点名称	Tn Antigen
別名	Tn Antigen antibody; Tn antigen antibody; Sialyl Tn antibody

属性

存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

全名	Antibody Duo for Tn Antigen (sTn, Tn)
研究领域	Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody

检测图片 (1)

ARG53971 anti-Sialyl Tn antibody [STn 219] FACS image
Flow Cytometry: MKN45 cells (orange, positive cell line) and KATO III cells (black, negative cell line) stained with ARG53971 anti-Sialyl Tn antibody [STn 219].

参考文献

Shigella flexneri Targets Human Colonic Goblet Cells by O Antigen Binding to Sialyl-Tn and Tn Antigens via Glycan-Glycan Interactions.

ARG53971: ICC/IF / Human

Elizabeth Ngoc Hoa Tran et al.
ACS Infect Dis., (2020)