TSG101 Rabbit Monoclonal Antibody

Key features and details

Reactivity:Human
Application:WB, IHC-P
Host:Rabbit
Clonality:Monoclonal
lsotype:IgG
Target:TSG101

Brand:

CAT.NO. : ARA6814

RMB Please choose

Size:

100μL

Trail, Bulk size or Custom requests Please contact us

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Product Details

Background

The transformation of a normal cell to one that is malignant can result from mutations in genes that encode proteins with key regulatory functions. Examples include the retinoblastoma gene product (Rb p110), p53, VHL and APC. Using a novel cloning strategy that allows the isolation of previously uncharacterized genes encoding selectable recessive phenotypes, an additional tumor suppressor gene has been identified. This gene, termed tsg 101 for tumor susceptibility gene 101, encodes a stathmin binding domain protein. When expression of this growth inhibitory gene is blocked in NIH/3T3 cells using antisense mRNA, the cells exhibit a transformed phenotype and are tumorigenic in SL6 mice.

Application

Application	Dilution Ratio
IHC-P	1:500 - 1:1000

Overview

Antibody Type	Recombinant Rabbit monoclonal Antibody
Immunogen	Synthetic peptide within Human TSG101 aa 24-73 / 390.
Species Reactivity	Human, Mouse, Rat
Validated Applications	WB, IF-Cell, IF-Tissue, IHC-P, FC
Molecular Weight	Predicted band size: 44 kDa
Positive Control	HeLa cell lysate, K-562 cell lysate, MCF7 cell lysate, Jurkat cell lysate, C2C12 cell lysate, PC-12 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, HeLa, NIH/3T3, PC-12, human kidney tissue, mouse colon tissue, mouse kidney tissue, human colon carcinoma tissue.
Conjugation	unconjugated
RRID	AB_3068599
Form	Liquid
Storage Buffer	1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide
Isotype	IgG
Purification Method	Protein A affinity purified